Latanoprost is the most widely used prostaglandin for the treatment of elevated IOP in glaucoma. Latanoprost is manufactured at Cayman Chemical in Ann Arbor, MI and at Cayman Pharma, our Czech subsidiary. Both companies have a complete DMF; between the two companies the DMF/ASMF is on file with the US FDA, Canada, India, in several EU member states, and in several other countries.