(+)-Cloprostenol (sodium salt)
Product Name
| Alternative name |
(+)-(16-m-chlorophenoxy)-17,18,19,20-tetranor-Prostaglandin F2α sodium salt |
| Brand name |
Acceleration D™, Bioprost-D™, Cicloprostag™, Dalmaprost™, Dalmazin™, Genestran™, Preloban™, Presolvin C™, Prolise™, Veteglan™ |
| Chemical name |
(+)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, (sodium salt) |
| Synonym |
|
| CAS number |
62561-03-9 |
Formula
| Formula |
C22H28O6Cl · Na |
| Relative molecular weight |
446.90 |
| Structure |
|
Physiochemical data
| Solubility |
| Water |
soluble |
| Ethanol 95% |
soluble |
| Acetone |
slightly soluble |
| Chloroform |
slightly soluble |
| Ether |
slightly soluble |
| Hexane |
insoluble |
|
| Appearance |
white to off-white, hygroscopic powder |
| Melting point range |
89 - 104°C |
| pH value |
1% aqueous suspension has pH value about 7.5. |
| Crystallinity |
The crystallinity of the product has been verified in a Nujol suspension using polarized light; the bifringence under these conditions was not observed, confirming the amorphous nature of the substance. |
Principal analytical parameters
| Assay (as per BVP 2002) |
97.0 - 101.0% abs. |
| Impurities total (as per BVP 2002) |
max. 2.5% rel. |
| Purity (HPLC) |
|
| (+)-Cloprostenol |
min. 97.0% rel. |
| 15S-(+)-cloprostenol |
max. 0.5% rel. |
| 5,6-trans-(+)-cloprostenol |
max. 2.0% rel. |
| Other impurities single |
max. 0.1% rel |
| Other impurities total |
max. 0.3% rel. |
| Optical rotation |
[α]D25 = +25.0° to +30.0° (c=1, ethanol) |
| Water |
max. 3.0% abs. |
Product quality complies EP 2002 for category 2 and 3A of non-sterile products. Complete specification is available upon request.
Storage and stability
The product is stored in a refrigerator at temperatures between 2 - 8°C in a dry (desiccator) and dark place. Retest time is 12 months in immediate packaging (broad-necked NALGENE of HDPE) under these conditions.
Use
+ Cloprostenol is the active enantiomer of Cloprostenol. Cloprostenol is used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses.
