Travoprost
Product Name
| Alternative name |
(+)-16-m-trifluoromethylphenoxy tetranor Prostaglandin F2α isopropyl ester; (+)-Fluprostenol ispopropyl ester |
| Brand name |
Travatan™ |
| Chemical name |
(+)-(5Z,9α,1α,13E,15R)-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5,13-dien-1-oic acid, isopropyl ester |
| CAS number |
157283-68-6 |
Formula
| Formula |
C26H35F3O6 |
| Relative molecular weight |
500.6 |
| Structure |
|
Physiochemical data
| Solubility |
| Water |
slightly soluble |
| Ethanol |
very soluble |
| Methanol |
very soluble |
| Chloroform |
very soluble |
|
|
| Acetonitrile |
very soluble |
|
| Appearance |
clear, colorless to slightly yellow oil |
| Melting point range |
liquid oil does not solidify below -50 °C |
| Optical rotation |
+14.6° (CH2Cl2, c=10 mg/mL) |
| pH value |
solution in water has pH value about 6.0 |
Storage and stability
The product is packaged in HDPE bottles placed in PE Aluminium sachets protecting from humidity and light assault. Store in a freezer under temperatures below -18 °C on a dry, dark place.
Use
Travoprost is a potent FP receptor agonist that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma.
