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Superphan

Product Name

Alternative name	10% ethanolic solution of (+)-Cloprostenol
Chemical name	(+)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid
CAS number	54276-21-0

Formula

Formula	C₂₂H₂₉O₆Cl
Relative molecular weight	424.92
Structure

Physiochemical data

Superphan is a clear, colorless to slightly yellowish liquid. The solution contains approximately 10% of biologically active substance (+)-Cloprostenol in ethanol.

Solubility

Ethanol	very soluble
Acetone	very soluble
Chloroform	soluble
Ethyl ether	slightly soluble
Water	very slightly soluble

Principal analytical parameters

Concentration	9.0 - 11.0% w/w
Purity (HPLC)
(+)-Cloprostenol	min. 97.5% rel.
15S-(+)-cloprostenol	max. 0.3% rel.
5,6-trans-(+)-cloprostenol	max. 2.0% rel.
Other impurities single	max. 0.1% rel.
Other impurities total	max. 0.3% rel.
Optical rotation	[α]_D²⁵ = +20° to +25° (c=1, ethanol)

Product quality complies EP 2002 for category 2 and 3A of non-sterile products. Complete specification is available upon request.

Storage and stability

The product is stored in a freezer at temperatures below -18°C in a dry and dark place. Retest time is 18 months in immediate packaging (bottle DURAN of borosilicate glass fitted with PP closure and seal ring) under these conditions.

Use

Superphan is a 10% ethanolic solution of (+)-Cloprostenol. Cloprostenol is used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses