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Epoprostenol sodium salt
Product Name
| Alternative name |
Prostaglandin I2 sodium salt |
| Brand name |
Flolan™ |
| Chemical name |
(5Z,6,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxy-prosta-5,13-dien-1-oic acid, sodium salt |
| CAS number |
61849-14-7 |
Formula
| Formula |
C20H31O5 · Na |
| Relative molecular weight |
374.5 |
| Structure |
|
Physiochemical data
| Solubility |
| Water |
very soluble |
| Ethanol |
very soluble |
| Methanol |
very soluble |
| Acetonitrile |
slightly soluble |
|
| Appearance |
Slightly grayish, crystalline material of felt-like structure, easily gaining and |
| Melting point range |
164.0 — 165.5 °C (plate), 162.2 — 178.8 °C (capillary) |
| Optical rotation |
[α]D25= +88° (c = 0.8 mg/mL, CHCl3), +97° (c = 0.8 mg/mL, 95 % ethanol) |
| pH value |
1 % aqueous solution has pHbn value 10.561 % aqueous solution has pH value 10.56 |
| Other data |
Material is highly hygroscopic from approx. 50 % RH; it is unstable in acid and neutral milieu. |
Storage and stability
The product is packaged in HDPE bottles placed in PE Aluminium sachets protecting from humidity and light assault. Store in a freezer under temperatures below -18 °C on a dry, dark place.
Use
Epoprostenol is a potent vasodilator and antiplatelet substance with a very short physiologic half life. It is used for the treatment of pulmonary hypertension.
